Indications for the use of Lupron Depot:
Endometriosis (occurrence in various organs tissue areas that are similar in structure to the uterine lining, and are subjected to cyclic changes in menstrual cycle, respectively) to reduce the pain and regression (return of) intrauterine lesions, palliative (a debilitating manifestation of the disease, but does not eliminate it cause) treatment for prostate cancer as an alternative means when orchiectomy (surgical removal of the testes) or the use of estrogen (female hormone) is unacceptable to treat a particular patient.
Pharmacological effect of Lupron Depot:
Synthetic analogue of gonadotropin-releasing hormone. In the early use of the product increases the secretion of pituitary gonadotropins (pituitary hormones that stimulate the activity of sex glands). With the systematic use of the product arises receptor desensitization (decrease in the number of formations on the surface of pituitary cells responsive to gonadtropin-releasing hormone) and decrease the secretion of gonadotropins (pituitary hormones that stimulate the activity of sexual glands) and sex hormones.
This effect is reversible, and subsequently eliminate the use of the product physiological hormone secretion is restored.
Intramuscular injection of a suspension of the product leads to the formation of intramuscular depot of a medicinal product that allows you to maintain an effective concentration of the product for a month. The introduction of 7.7 mg of the product in men initially registered a sharp increase in product concentration in blood plasma, then its level in plasma is stabilized (0.80 ng / ml) was subsequently following a slow decline for several weeks. Bioavailability of the product within 90%.
Lupron Depot Dosage and administration:
Lupron Depot Injection of the product make a once a month. Dose of the product is determined individually in each case.
In the case of preservation of menstrual function during treatment product, you must notify your doctor.
Recommended course duration of 6 months.
During the reception of the product for contraceptive purposes should not use hormonal contraceptives. In the case of pregnancy the treatment should be stopped.
Lupron Depot contraindications:
Increased susceptibility to gonadotropinrilizing hormone and its analogs, uterine bleeding, undiagnosed origin (unknown causes), pregnancy, breast-feeding.
Smoking and regular alcohol consumption increases the risk of osteoporosis (bone eating disorders, accompanied by an increase in its fragility).
Lupron Depot side effects:
In the treatment of leuprorelin may experience symptoms of patients with decreased secretion of estrogen. After completion of treatment estrogen levels gradually reach normal values.
Induced gipoestrogenny status (reduction under the action of the product levels of estrogen in the body) leads to a decrease in bone density during treatment. At 6-month course of treatment these changes are expressed nekordinalno.
